Stafford was the son of one of Gerion Lannister's younger brothers, Tygett. He served the Lannisters of Casterly Rock in his adulthood as an advisor on the Lords' counsel. He has nine children with his wife, Olene Lannister.
Stafford served as the Master of Laws for the King's Small Council temporarily when Nathaniel Arryn took the position of Hand of the King upon Loren's death. After Eon Crakehall arrived to assume the duties, Stafford returned to his advisor role. Damon Lannister continued to rely heavily on Stafford, often using him to fill in the gaps in other small council members' competencies.
Stafford worked closely with Aemon Estermont in the reconstruction of the royal fleet.
When Damon Lannister returned from the Westerlands, Stafford demanded that Benfred Tanner (who slew his oldest son Gunthor in a trial by combat on Fair Isle) be sent away. When Damon refused, Stafford resigned from his role and returned to Lannisport.
"Stafford had hung up his sword belt hardly a moon's turn after his anointment, decades past now, the slender and bookish man always better fit for a council table than a battlefield." - Blood and Whispers
“I will look as awful as you do, with those terrible circles beneath your eyes. Maybe I will have Lord Arryn take a mailed elbow to the face as well, that way all my advisors and I can be haggard looking men.” -Damon Lannister
Olene Lannister, wife
Gunthor Lannister, son
Tygett Lannister, son
Maslyn Lannister, daughter
Six other unnamed children